Efficacy and Safety of Timothy Grass Allergy Immunotherapy Tablets in North American Children and Adolescents
نویسنده
چکیده
CONCLUSIONS. Although all SLIT regimens resulted in an improvement in clinical efficacy, prolonged SLIT was the most effective. The reduction in IL-4 and increase in IL-10 production is consistent with observations from subcutaneous immunotherapy studies and provides insight into the mechanism of SLIT. These cytokine changes might serve as an objective marker of efficacy of SLIT for patients on treatment.
منابع مشابه
Efficacy and Safety of Timothy Grass Allergy Immunotherapy Tablets in North American Children and Adolescents
CONCLUSIONS. Although all SLIT regimens resulted in an improvement in clinical efficacy, prolonged SLIT was the most effective. The reduction in IL-4 and increase in IL-10 production is consistent with observations from subcutaneous immunotherapy studies and provides insight into the mechanism of SLIT. These cytokine changes might serve as an objective marker of efficacy of SLIT for patients on...
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STUDY POPULATION. Subjects were 278 children (age: 5–14 years) with seasonal grass pollen-induced allergic rhinoconjunctivitis for 2 years. Allergy was confirmed by a timothy grass-specific immunoglobulin E (IgE) level of at least class 2 and a wheal diameter of 3 mm in a skin-prick test containing 5 grass pollens included in the SLIT tablet (orchard, meadow, perennial rye, sweet vernal, and ti...
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BACKGROUND The efficacy and safety of the 300-index of reactivity (IR) dose of 5-grass-pollen sublingual immunotherapy (SLIT) tablets (Stallergènes, Antony, France) have been demonstrated for the treatment of hay fever in adults. OBJECTIVE We sought to assess the efficacy and safety of this tablet in children and adolescents with grass pollen-related allergic rhinitis. METHODS In this multi...
متن کاملEfficacy and safety of MK-7243: a grass allergy sublingual immunotherapy tablet evaluated in Canadian adults and children
Background The effect of MK-7243 (2800 BAU/75,000 SQ [~15 μg of Phleum pratense p 5], Merck/ALK-Abelló), a sublingual Timothy grass immunotherapy tablet, has been evaluated in several randomized, placebo-controlled, double-blind trials; three of these trials were conducted in adults and children in North America (the United States and Canada) who have allergic rhinitis with or without conjuncti...
متن کاملThe efficacy and safety of the Timothy grass allergy sublingual immunotherapy tablet in Canadian adults and children
BACKGROUND The effect of sublingual Timothy grass immunotherapy tablet 2800 BAU (grass SLIT-T) has been evaluated in three North American trials in adults and children who have allergic rhinitis with or without conjunctivitis (AR/C). This paper examines the effects of grass SLIT-T in Canadians. METHODS Data for grass-allergic Canadians in three randomized, placebo-controlled, double-blind tri...
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